Product Name :
VU0155041 sodium
Description:
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson’s disease (PD).
CAS:
1259372-69-4
Molecular Weight:
338.16
Formula:
C14H14Cl2NNaO3
Chemical Name:
sodium (1S,2R)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylate
Smiles :
O=C(O[Na])[C@H]1CCCC[C@H]1C(=O)NC1C=C(Cl)C=C(Cl)C=1
InChiKey:
ZFDOLOCYGVTGDQ-LYCTWNKOSA-M
InChi :
InChI=1S/C14H15Cl2NO3.Na/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20;/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20);/q;+1/p-1/t11-,12+;/m1./s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson’s disease (PD).|Product information|CAS Number: 1259372-69-4|Molecular Weight: 338.16|Formula: C14H14Cl2NNaO3|Chemical Name: sodium (1S,2R)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylate|Smiles: O=C(O[Na])[C@H]1CCCC[C@H]1C(=O)NC1C=C(Cl)C=C(Cl)C=1|InChiKey: ZFDOLOCYGVTGDQ-LYCTWNKOSA-M|InChi: InChI=1S/C14H15Cl2NO3.Na/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20;/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20);/q;+1/p-1/t11-,12+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: 10 mM in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Fidaxomicin Protocol |Shelf Life: ≥12 months if stored properly.Elacestrant site |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33007509 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons.|In Vivo:|VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats. VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats.|References:|Mironov AA, Beznoussenko GV, Nicoziani P, Martella O, Trucco A, Kweon H, Giandomenico DD, Polishchuk RS, Fusella A, Lupetti P, Berger EG, Geerts WJC, Koster AJ, Burger KNJ, Luini A (2001). “Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae”. JCB 155 (7): 1225-38.Products are for research use only. Not for human use.|