Product Name :
8-Azaguanine
Description:
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.
CAS:
134-58-7
Molecular Weight:
152.11
Formula:
C4H4N6O
Chemical Name:
5-amino-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one
Smiles :
NC1NC(=O)C2N=NNC=2N=1
InChiKey:
LPXQRXLUHJKZIE-UHFFFAOYSA-N
InChi :
InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Diclofenac Immunology/Inflammation
Shelf Life:
≥12 months if stored properly.Annexin V-FITC/PI Apoptosis Detection Kit Purity
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33222098
Additional information:
8-Azaguanine is a purine analogue that shows antineoplastic activity. 8-Azaguanine functions as an antimetabolite and easily incorporates into ribonucleic acids, interfering with normal biosynthetic pathways, thus inhibiting cellular growth.|Product information|CAS Number: 134-58-7|Molecular Weight: 152.11|Formula: C4H4N6O|Chemical Name: 5-amino-3H,6H,7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one|Smiles: NC1NC(=O)C2N=NNC=2N=1|InChiKey: LPXQRXLUHJKZIE-UHFFFAOYSA-N|InChi: InChI=1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 2.44 mg/mL (16.04 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|8-Azaguanine induces a decrease in cell viability in a dose, time and cell type dependent manner with MOLT3 cells being the most sensitive to 8-Azaguanine citotoxic effects (24h IC50: 10 μM) when compared with CEM cells (24h IC50: 100 μM). MOLT3 cell treated with 8-Azaguanine shows an increase in CD26 expression (MIF) compared with that of CEM cell submitted to the same conditions (65.4 versus 18.7).|References:|Dourado M, et al. CD26/DPPIV expression and 8-azaguanine response in T-acute lymphoblastic leukaemia cell lines in culture. Pathophysiology. 2007 May;14(1):3-10.Products are for research use only. Not for human use.|