Product Name :
JNJ-63533054
Description:
JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable.
CAS:
1802326-66-4
Molecular Weight:
316.78
Formula:
C17H17ClN2O2
Chemical Name:
3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide
Smiles :
C[C@H](NC(=O)CNC(=O)C1=CC(Cl)=CC=C1)C1C=CC=CC=1
InChiKey:
MWDVCHRYCKXEBY-LBPRGKRZSA-N
InChi :
InChI=1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{N-Boc-piperazine} web|{N-Boc-piperazine} PROTAC Linkers|{N-Boc-piperazine} TGF-beta/Smad|{N-Boc-piperazine} Biological Activity|{N-Boc-piperazine} References|{N-Boc-piperazine} manufacturer}
Shelf Life:
≥12 months if stored properly.{{Fontolizumab} web|{Fontolizumab} IFNAR|{Fontolizumab} Activator|{Fontolizumab} Biological Activity|{Fontolizumab} Purity|{Fontolizumab} manufacturer}
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32472497
Additional information:
JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM) that is brain and cell penetrant. JNJ 63533054 is selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142 and is orally bioavailable.|Product information|CAS Number: 1802326-66-4|Molecular Weight: 316.78|Formula: C17H17ClN2O2|Synonym:|JNJ 63533054|JNJ63533054|JNJ-63533054|Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide|Smiles: C[C@H](NC(=O)CNC(=O)C1=CC(Cl)=CC=C1)C1C=CC=CC=1|InChiKey: MWDVCHRYCKXEBY-LBPRGKRZSA-N|InChi: InChI=1S/C17H17ClN2O2/c1-12(13-6-3-2-4-7-13)20-16(21)11-19-17(22)14-8-5-9-15(18)10-14/h2-10,12H,11H2,1H3,(H,19,22)(H,20,21)/t12-/m0/s1|Technical Data|Appearance: Solid Power.|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: Soluble in DMSO, not in water|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined.|HS Tariff Code: 382200|References:|Liu C, Bonaventure P, Lee G, Nepomuceno D, Kuei C, Wu J, Li Q, Joseph V, Sutton SW, Eckert W, Yao X, Yieh L, Dvorak C, Carruthers N, Coate H, Yun S, Dugovic C, Harrington A, Lovenberg TW. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015 Nov;88(5):911-25. doi: 10.1124/mol.115.100412. Epub 2015 Sep 8. PubMed PMID: 26349500.Products are for research use only. Not for human use.|