Tankyrase-tankyrase.com

Additional information:
Iriflophenone 3-C-β-D-glucopyranoside, isolated from Cyclopia genistoides, has antioxidant activity.|Product information|CAS Number: 104669-02-5|Molecular Weight: 408.36|Formula: C19H20O10|Synonym:|Iriflophenone 3-C-β-D-glucopyranoside|Chemical Name: (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-[2,4,6-trihydroxy-3-(4-hydroxybenzoyl)phenyl]oxane-3,4,5-triol|Smiles: OC[C@H]1O[C@H]([C@H](O)[C@@H](O)[C@@H]1O)C1=C(O)C(C(=O)C2C=CC(O)=CC=2)=C(O)C=C1O|InChiKey: BZYKNVLTMWYEFA-ZJKJAXBQSA-N|InChi: InChI=1S/C19H20O10/c20-6-11-15(25)17(27)18(28)19(29-11)13-10(23)5-9(22)12(16(13)26)14(24)7-1-3-8(21)4-2-7/h1-5,11,15,17-23,25-28H,6H2/t11-,15-,17+,18-,19+/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:33342021 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|References:|Malherbe CJ, et al. Iriflophenone-3-C-glucoside from Cyclopia genistoides: isolation and quantitative comparison of antioxidant capacity with mangiferin and isomangiferin using on-line HPLC antioxidant assays. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:164-71.Products are for research use only. Not for human use.|

Additional information:
VU0155041 sodium is a potent, selective positive allosteric modulator (PAM) of mGluR4, with EC50s of 798 nM and 693 nM for human and rat mGluR4, respectively. VU0155041 has potential for the research of Parkinson’s disease (PD).|Product information|CAS Number: 1259372-69-4|Molecular Weight: 338.16|Formula: C14H14Cl2NNaO3|Chemical Name: sodium (1S,2R)-2-[(3,5-dichlorophenyl)carbamoyl]cyclohexane-1-carboxylate|Smiles: O=C(O[Na])[C@H]1CCCC[C@H]1C(=O)NC1C=C(Cl)C=C(Cl)C=1|InChiKey: ZFDOLOCYGVTGDQ-LYCTWNKOSA-M|InChi: InChI=1S/C14H15Cl2NO3.Na/c15-8-5-9(16)7-10(6-8)17-13(18)11-3-1-2-4-12(11)14(19)20;/h5-7,11-12H,1-4H2,(H,17,18)(H,19,20);/q;+1/p-1/t11-,12+;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: 10 mM in DMSO|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Fidaxomicin Protocol |Shelf Life: ≥12 months if stored properly.Elacestrant site |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33007509 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|VU0155041 (10 μM) does not affect NMDA receptor currents in striatal medium spiny neurons.|In Vivo:|VU0155041 (31 nmol, 93 nmol; i.c.v.) reverses catalepsy induced by the dopamine D2 receptor antagonist Haloperidol (1.5 mg/kg, i.p.) in rats. VU0155041 (93 nmol, 316 nmol; i.c.v.) reverses Reserpine (HY-N0480) -induced akinesia in rats.|References:|Mironov AA, Beznoussenko GV, Nicoziani P, Martella O, Trucco A, Kweon H, Giandomenico DD, Polishchuk RS, Fusella A, Lupetti P, Berger EG, Geerts WJC, Koster AJ, Burger KNJ, Luini A (2001). “Small cargo proteins and large aggregates can traverse the Golgi by a common mechanism without leaving the lumen of cisternae”. JCB 155 (7): 1225-38.Products are for research use only. Not for human use.|

Additional information:
Cysteine Thiol Probe is a thiol-based probe designed to label electrophilic natural products. Cysteine Thiol Probe possesses each of the characteristics of an ideal pharmacophore probe, and has a chromophore. Cysteine Thiol Probe is capable of engaging enone-, β-lactam-, and β-lactone-based electrophilic metabolites.|Product information|CAS Number: 1947408-74-3|Molecular Weight: 318.19|Formula: C11H12BrNO3S|Chemical Name: methyl (2R)-2-[(4-bromophenyl)formamido]-3-sulfanylpropanoate|Smiles: COC(=O)[C@H](CS)NC(=O)C1C=CC(Br)=CC=1|InChiKey: QLAHQHTYCQKQLI-VIFPVBQESA-N|InChi: InChI=1S/C11H12BrNO3S/c1-16-11(15)9(6-17)13-10(14)7-2-4-8(12)5-3-7/h2-5,9,17H,6H2,1H3,(H,13,14)/t9-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 250 mg/mL (785.69 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Cysteine Thiol Probe (Probe 1) reacts much more readily with β-lactam- and β-lactone-based electrophilic natural products, and its reactivity with epoxide-based electrophilic natural products is poor.Artesunate Epigenetics And probe 2 reacts much faster with epoxide-containing natural products.Omidenepag Technical Information This orthogonal reactivity allows them to be employed in extracts simultaneously.PMID:33306604 Since Cysteine Thiol Probe is brominated and probe 2 is chlorinated, the isotopic patterns of labeled natural products point toward their structural origin. Competition experiments using Cysteine Thiol Probe and 2 indicated that brominated Cysteine Thiol Probe reacted exclusively with the β-lactam in penicillin G and the β-lactone in salinosporamide A while chlorinated probe 2 alone reacted with the epoxide in salinamide A.|References:|Castro-Falcon G, et al. Thiol Probes To Detect Electrophilic Natural Products Based on Their Mechanism of Action. ACS Chem Biol. 2016 Aug 19;11(8):2328-36.Reimer D, et al. Thiol-Based Probe for Electrophilic Natural Products Reveals That Most of the Ammosamides Are Artifacts. J Nat Prod. 2017 Jan 27;80(1):126-133.Products are for research use only. Not for human use.|

Additional information:
VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a synthesized E3 ligase ligand-linker conjugate that incorporates the VH032 based VHL ligand and a linker used in PROTAC technology.|Product information|CAS Number: 2098836-63-4|Molecular Weight: 589.81|Formula: C29H43N5O4S2|Chemical Name: (2S,4R)-1-[(2R)-3-[(6-aminohexyl)sulfanyl]-2-acetamido-3-methylbutanoyl]-4-hydroxy-N-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methylpyrrolidine-2-carboxamide|Smiles: CC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCC1=CC=C(C=C1)C1SC=NC=1C)C(C)(C)SCCCCCCN|InChiKey: GRWPLYITJSUPHS-RMTZWNOUSA-N|InChi: InChI=1S/C29H43N5O4S2/c1-19-25(39-18-32-19)22-11-9-21(10-12-22)16-31-27(37)24-15-23(36)17-34(24)28(38)26(33-20(2)35)29(3,4)40-14-8-6-5-7-13-30/h9-12,18,23-24,26,36H,5-8,13-17,30H2,1-4H3,(H,31,37)(H,33,35)/t23-,24+,26-/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: To be determined|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Volanesorsen manufacturer |Shelf Life: ≥12 months if stored properly.Vortioxetine supplier |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33148927 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|VH032-thiol-C6-NH2 (VHL Ligand-Linker Conjugates 14) is a compound binding to BRD4, used to inhibit BRD4 based on PROTAC.|References:|Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.Products are for research use only. Not for human use.|

Additional information:
Bisphenol B has a binding affinity for estrogen receptors.Drospirenone site |Product information|CAS Number: 859-18-7|Molecular Weight: 443.00|Formula: C18H35ClN2O6S|Synonym:|Lincocin|U-10149A|U10149A|U 10149A|Chemical Name: (2S,4R)-N-[(1R,2R)-2-hydroxy-1-[(2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylsulfanyl)oxan-2-yl]propyl]-1-methyl-4-propylpyrrolidine-2-carboxamide hydrochloride|Smiles: Cl.C[C@@H](O)[C@@H](NC(=O)[C@@H]1C[C@@H](CCC)CN1C)[C@H]1O[C@H](SC)[C@H](O)[C@@H](O)[C@H]1O|InChiKey: POUMFISTNHIPTI-BOMBIWCESA-N|InChi: InChI=1S/C18H34N2O6S.PMID:33001710 ClH/c1-5-6-10-7-11(20(3)8-10)17(25)19-12(9(2)21)16-14(23)13(22)15(24)18(26-16)27-4;/h9-16,18,21-24H,5-8H2,1-4H3,(H,19,25);1H/t9-,10-,11+,12-,13+,14-,15-,16-,18-;/m1./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.|Product information|CAS Number: 68786-66-3|Molecular Weight: 359.66|Formula: C14H9Cl3N2OS|Synonym:|Fasinex|CGA89317|Egaten|Endex-K|Chemical Name: 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole|Smiles: CSC1NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N=1|InChiKey: NQPDXQQQCQDHHW-UHFFFAOYSA-N|InChi: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Additional information:
GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson’s disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application.Droxidopa Purity GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.|Product information|CAS Number: 76778-22-8|Molecular Weight: 414.58|Formula: C28H34N2O|Synonym:|GBR12935|GBR-12935|Chemical Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine|Smiles: C(CCN1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1)C1C=CC=CC=1|InChiKey: RAQPOZGWANIDQT-UHFFFAOYSA-N|InChi: InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Telmisartan Biological Activity |Shelf Life: ≥12 months if stored properly.PMID:32639854 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|