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Triclabendazole

Product Name :
Triclabendazole

Description:
Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.

CAS:
68786-66-3

Molecular Weight:
359.Molnupiravir Epigenetic Reader Domain 66

Formula:
C14H9Cl3N2OS

Chemical Name:
5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole

Smiles :
CSC1NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N=1

InChiKey:
NQPDXQQQCQDHHW-UHFFFAOYSA-N

InChi :
InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Dimethyl sulfoxide Bacterial

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:33316085

Additional information:
Triclabendazole is an anthelmintic and fasciolicidal, binding to beta-tubulin and preventing the polymerization of the microtubules of which they are part. Studies in vitro and/or in infected animals suggest that triclabendazole and its active metabolites (sulfoxide and sulfone) are absorbed by the tegument of the immature and mature worms, leading to a decrease of the resting membrane potential, inhibition of tubulin function as well as protein and enzyme synthesis. These metabolic disturbances are associated with inhibition of motility, disruption of the surface as well as ultrastructure that includes inhibition of spermatogenesis and vitelline cells.|Product information|CAS Number: 68786-66-3|Molecular Weight: 359.66|Formula: C14H9Cl3N2OS|Synonym:|Fasinex|CGA89317|Egaten|Endex-K|Chemical Name: 5-chloro-6-(2,3-dichlorophenoxy)-2-(methylsulfanyl)-1H-1,3-benzodiazole|Smiles: CSC1NC2=CC(OC3=CC=CC(Cl)=C3Cl)=C(Cl)C=C2N=1|InChiKey: NQPDXQQQCQDHHW-UHFFFAOYSA-N|InChi: InChI=1S/C14H9Cl3N2OS/c1-21-14-18-9-5-8(16)12(6-10(9)19-14)20-11-4-2-3-7(15)13(11)17/h2-6H,1H3,(H,18,19)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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GBR 12935

Product Name :
GBR 12935

Description:
GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson’s disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application. GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.

CAS:
76778-22-8

Molecular Weight:
414.58

Formula:
C28H34N2O

Chemical Name:
1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine

Smiles :
C(CCN1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1)C1C=CC=CC=1

InChiKey:
RAQPOZGWANIDQT-UHFFFAOYSA-N

InChi :
InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
GBR-12935 is a piperazine derivative which is a potent and selective dopamine reuptake inhibitor. It was originally developed in its 3H radiolabelled form for the purpose of mapping the distribution of dopaminergic neurons in the brain by selective labelling of dopamine transporter proteins. This has led to potential clinical uses in the diagnosis of Parkinson’s disease, although selective radioligands such as Ioflupane (¹²³I) are now available for this application.Droxidopa Purity GBR-12935 is now widely used in animal research into Parkinson’s disease and the dopamine pathways in the brain.|Product information|CAS Number: 76778-22-8|Molecular Weight: 414.58|Formula: C28H34N2O|Synonym:|GBR12935|GBR-12935|Chemical Name: 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazine|Smiles: C(CCN1CCN(CCOC(C2C=CC=CC=2)C2C=CC=CC=2)CC1)C1C=CC=CC=1|InChiKey: RAQPOZGWANIDQT-UHFFFAOYSA-N|InChi: InChI=1S/C28H34N2O/c1-4-11-25(12-5-1)13-10-18-29-19-21-30(22-20-29)23-24-31-28(26-14-6-2-7-15-26)27-16-8-3-9-17-27/h1-9,11-12,14-17,28H,10,13,18-24H2|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Telmisartan Biological Activity |Shelf Life: ≥12 months if stored properly.PMID:32639854 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

Vimentin monoclonal antibody

Product Name :
Vimentin monoclonal antibody

Sequence:

Purity:

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Use/Stability :

Description:
Monoclonal antibody to Vimentin for use with IHC applications

CAS :

Solubility:

Formula:

Additional Information :
| Application IHC | Application Notes For IHC applications: Dilute the concentrate as appropriate in antibody diluent, and then apply 150 µL to the slide, as indicated in the user’s IHC protocol.1079774-23-4 supplier | Formulation Liquid.946414-94-4 Purity & Documentation In Tris buffer, pH 7.PMID:29494001 5, containing 1% BSA and | Host Mouse | Immunogen Recombinant vimentin. | Isotype IgG | Recommendation Dilutions/Conditions Immunohistochemistry (1:50-1:100)Optimal conditions must be determined individually for each application. | Species Reactivity Human | UniProt ID P08670 | Unit of Measure (UM) ml, µl

Rimantadine Hydrochloride

Product Name :
Rimantadine Hydrochloride

Description:
Rimantadine is an orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection. When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. Both rimantadine and the similar drug amantadine are derivates of adamantane.

CAS:
1501-84-4

Molecular Weight:
215.76

Formula:
C12H22ClN

Chemical Name:
1-(adamantan-1-yl)ethan-1-amine hydrochloride

Smiles :
Cl.CC(N)C12CC3CC(C1)CC(C2)C3

InChiKey:
OZBDFBJXRJWNAV-UHFFFAOYSA-N

InChi :
InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.Clarithromycin Formula

Additional information:
Rimantadine is an orally administered antiviral drug used to treat, and in rare cases prevent, influenzavirus A infection.Pretomanid Technical Information When taken within one to two days of developing symptoms, rimantadine can shorten the duration and moderate the severity of influenza. Both rimantadine and the similar drug amantadine are derivates of adamantane.|Product information|CAS Number: 1501-84-4|Molecular Weight: 215.76|Formula: C12H22ClN|Synonym:|Flumadine hydrochloride|Chemical Name: 1-(adamantan-1-yl)ethan-1-amine hydrochloride|Smiles: Cl.PMID:33252208 CC(N)C12CC3CC(C1)CC(C2)C3|InChiKey: OZBDFBJXRJWNAV-UHFFFAOYSA-N|InChi: InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

TRAIL-R1 (human) monoclonal antibody (DJR1)

Product Name :
TRAIL-R1 (human) monoclonal antibody (DJR1)

Sequence:

Purity:

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Description:
DR4 is 56kDa member 10A of the TNFR superfamily (TNFRSF10A), also known as TRAIL-R1, Apo-2, and CD261.3025082-14-5 Protocol It is expressed at low levels by activated T cells and some tumors. After TRAIL engagement, DR4 (TRAIL-R1), through activation of NF-κB, induces apoptosis in the TRAIL ligated cell.

CAS :

Solubility:

Formula:

Additional Information :
| Alternative Name TRAIL receptor 1, Apo-2, CD261, DR4, Death receptor 4, TNFRSF 10A, TNF-related apoptosis-inducing ligand receptor 1, Tumor necrosis factor receptor superfamily member 10A | Application Flow Cytometry, WB | Clone DJR1 | Formulation Liquid.1353485-38-7 Data Sheet In PBS, pH 7.PMID:30969537 2, containing 0.09% sodium azide. | GenBank ID U90875 | Gene/Protein Identifier 8798 (Entrez GeneID) | Host Mouse | Immunogen Recombinant human TRAIL-R1 extracellular domain IgG1 Fc fusion protein. | Isotype IgG1 | Species Reactivity Human | UniProt ID O00220 | Unit of Measure (UM) µg

Cimiracemoside D

Product Name :
Cimiracemoside D

Description:
Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.

CAS:
290821-39-5

Molecular Weight:
678.85

Formula:
C37H58O11

Chemical Name:
(2R,3S,4R,7R,9S,12R,14R,16R,17R,18R,19R,21R,22S)-2-hydroxy-22-(2-hydroxypropan-2-yl)-3,8,8,17,19-pentamethyl-9-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-23,24-dioxaheptacyclo[19.2.1.0¹,¹⁸.0³,¹⁷.0⁴,¹⁴.0⁷,¹².0¹²,¹⁴]tetracosan-16-yl acetate

Smiles :
C[C@@H]1C[C@H]2OC3(O[C@@H]2C(C)(C)O)[C@H]1[C@@]1(C)[C@@H](C[C@@]24C[C@]52CC[C@H](O[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC[C@H]4[C@]1(C)[C@H]3O)OC(C)=O

InChiKey:
HZIBYJCDCHVSPK-GKLVOFDRSA-N

InChi :
InChI=1S/C37H58O11/c1-17-13-20-28(32(5,6)43)48-37(47-20)27(17)34(8)24(45-18(2)38)14-36-16-35(36)12-11-23(46-29-26(41)25(40)19(39)15-44-29)31(3,4)21(35)9-10-22(36)33(34,7)30(37)42/h17,19-30,39-43H,9-16H2,1-8H3/t17-,19+,20-,21+,22+,23+,24-,25+,26-,27-,28+,29+,30-,33-,34-,35-,36+,37?/m1/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.

Shelf Life:
≥12 months if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.β-Muricholic acid web

Additional information:
Cimiracemoside D is a natural product found in Actaea racemosa with unknown details.|Product information|CAS Number: 290821-39-5|Molecular Weight: 678.85|Formula: C37H58O11|Chemical Name: (2R,3S,4R,7R,9S,12R,14R,16R,17R,18R,19R,21R,22S)-2-hydroxy-22-(2-hydroxypropan-2-yl)-3,8,8,17,19-pentamethyl-9-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxy-23,24-dioxaheptacyclo[19.2.1.0¹,¹⁸.0³,¹⁷.0⁴,¹⁴.0⁷,¹².0¹²,¹⁴]tetracosan-16-yl acetate|Smiles: C[C@@H]1C[C@H]2OC3(O[C@@H]2C(C)(C)O)[C@H]1[C@@]1(C)[C@@H](C[C@@]24C[C@]52CC[C@H](O[C@@H]2OC[C@H](O)[C@H](O)[C@H]2O)C(C)(C)[C@@H]5CC[C@H]4[C@]1(C)[C@H]3O)OC(C)=O|InChiKey: HZIBYJCDCHVSPK-GKLVOFDRSA-N|InChi: InChI=1S/C37H58O11/c1-17-13-20-28(32(5,6)43)48-37(47-20)27(17)34(8)24(45-18(2)38)14-36-16-35(36)12-11-23(46-29-26(41)25(40)19(39)15-44-29)31(3,4)21(35)9-10-22(36)33(34,7)30(37)42/h17,19-30,39-43H,9-16H2,1-8H3/t17-,19+,20-,21+,22+,23+,24-,25+,26-,27-,28+,29+,30-,33-,34-,35-,36+,37?/m1/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Obiltoxaximab Data Sheet |Shelf Life: ≥12 months if stored properly.PMID:32809360 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

TACI (mouse) monoclonal antibody (8F10)

Product Name :
TACI (mouse) monoclonal antibody (8F10)

Sequence:

Purity:

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Solubility :

Appearance:

Use/Stability :
Stable for at least 1 year after receipt when stored at -20°C.2390147-17-6 Purity & Documentation

Description:

CAS :

Solubility:

Formula:

Bornyl acetate

Product Name :
Bornyl acetate

Description:
Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor). Bornyl acetate possesses anti-cancer activity.

CAS:
76-49-3

Molecular Weight:
196.29

Formula:
C12H20O2

Chemical Name:
(1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.2.1]heptan-2-yl acetate

Smiles :
CC1(C)[C@@H]2C[C@@H](OC(C)=O)[C@@]1(C)CC2

InChiKey:
KGEKLUUHTZCSIP-HOSYDEDBSA-N

InChi :
InChI=1S/C12H20O2/c1-8(13)14-10-7-9-5-6-12(10,4)11(9,2)3/h9-10H,5-7H2,1-4H3/t9-,10+,12+/m0/s1

Purity:
≥98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.Abraxane In Vitro

Shelf Life:
≥360 days if stored properly.

Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.

Additional information:
Bornyl acetate is a potent odorant, exhibiting one of the highest flavor dilution factor (FD factor).Ryanodine Cancer Bornyl acetate possesses anti-cancer activity.|Product information|CAS Number: 76-49-3|Molecular Weight: 196.29|Formula: C12H20O2|Chemical Name: (1S, 2R, 4S)-1, 7, 7-trimethylbicyclo[2.PMID:33249548 2.1]heptan-2-yl acetate|Smiles: CC1(C)[C@@H]2C[C@@H](OC(C)=O)[C@@]1(C)CC2|InChiKey: KGEKLUUHTZCSIP-HOSYDEDBSA-N|InChi: InChI=1S/C12H20O2/c1-8(13)14-10-7-9-5-6-12(10,4)11(9,2)3/h9-10H,5-7H2,1-4H3/t9-,10+,12+/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 83.33 mg/mL (424.52 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥360 days if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|Bornyl acetate is characterized as one of the most important odorants of fresh ginger juice, as it exhibits one of the highest FD factors. Bornyl acetate is also identified as playing very important sensory roles in the aroma of fresh Japanese ginger. Bornyl acetate (0-96 μM) induces dose-dependent growth inhibitory efects on human gastric cancer cells in vitro. Combined effect of Bornyl acetate (48 μM) and 5-FU on SGC-7901 human gastric cancer cell death via apoptosis.|References:|Pang X, et al. Identification of Ginger (Zingiber officinale Roscoe) Volatiles and Localization of Aroma-Active Constituents by GC-Olfactometry. J Agric Food Chem. 2017 May 24;65(20):4140-4145.Juan Li, et al. Synergistic enhancement of the antitumor activity of 5-fuorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action. J BUON. Jan-Feb 2016;21(1):108-17.Products are for research use only. Not for human use.|

RSSR

Product Name :
RSSR

Sequence:

Purity:
≥97% (HPLC, GLC)

Molecular Weight:
344.5

Solubility :
Soluble in DMSO, water, 100% ethanol or methanol; DMSO is recommended for stock solution.

Appearance:
Off-white to yellow crystalline powder.

Use/Stability :
As indicated on product label or CoA when stored as recommended.

Description:
Supersensitive spin label Cell permeable supersensitive spin label (detection limit varies from 10nM to 100nM) for quick detection of reduced thiols using ESR. Allows following the reactions of sulfhydryl groups with RSSR to form thiol spin label adducts, for the monitoring of intracellular redox states of glutathione and other thiols.

CAS :
123557-49-3

Solubility:
Soluble in DMSO, water, 100% ethanol or methanol; DMSO is recommended for stock solution.548470-11-7 MedChemExpress

Formula:
C14H24N4O2S2

Additional Information :
| Alternative Name bis-(2,2,5,5-Tetramethyl-3-imidazoline-1-oxyl-4-yl)disulfide, biradical | Appearance Off-white to yellow crystalline powder.139290-65-6 In Vivo | CAS 123557-49-3 | Formula C14H24N4O2S2 | MW 344.PMID:30000740 5 | Purity ≥97% (HPLC, GLC) | Solubility Soluble in DMSO, water, 100% ethanol or methanol; DMSO is recommended for stock solution. | Unit of Measure (UM) mg

Proteasome ELISA kit

Product Name :
Proteasome ELISA kit

Sequence:

Purity:

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Appearance:

Use/Stability :
Stable for up to six months from receipt when stored at -20°C.

Description:
The only commercially available kit for proteasome quantification. Determination of 20S proteasome levels in biological samples (cell lysates, tissue extracts, plasma, serum) Comparison of 20S proteasome levels in plasma/serum samples associated with a particular disease/illness with samples from healthy controls Investigation of variation in 20S proteasome levels in abnormal cell lines/tissues This kit provides the means to quantify 20S proteasome concentrations in biological samples using a sandwich ELISA technique, utilizing two 20S proteasome specific antibodies for capture and detection purposes together with a highly sensitive substrate. Sample 20S proteasome levels are determined by comparison to a 20S proteasome calibration curve produced in parallel. This kit provides sufficient material for 1×96 well plate set-up to be run.Proteasomes are non-lysosomal proteolytic complexes localised primarily in the cytoplasm and in the nucleus of eukaryotic cells. The 26S proteasome structure is composed of a 20S proteasome catalytic core complex and one or two 19S regulatory subcomplexes. The 20S core comprises two copies of 14 subunits (7 α-subunits and 7 β-subunits) arranged in a α7β7β7α7 cylindrical array. Varying catalytic subunit composition (β1, β1i; β2, β2i; β5, β5i) results in a variety of possible subtypes. The 19S regulatory subcomplexes, comprised of 6 ATPase and at least 10 non-ATPase subunits, specifically bind ubiquitinylated proteins and provide the 20S core with an ATP-ubiquitin–dependent proteolytic activity. The ubiquitin-proteasome system is the major non-lysosomal system for the degradation of short half-life proteins and peptides that are involved in basic cellular processes, such as cell-cycle regulation and apoptosis, transcriptional regulation, or antigen processing. Thus, protein degradation by the ubiquitin-proteasome pathway has a major regulatory function for proliferation activity and survival of both normal and malignant cells. The 20S proteasome has been detected in normal human blood plasma (known as circulating proteasome), possessing comparatively low specific activity and with a distinct pattern of subtypes. Proteasomes are often overexpressed in cancer cells; abnormally high expression of proteasomes having been found in human leukaemia cells, renal cancer cells and in breast cancer cell lines. In patients suffering from auto-immune diseases, malignant myelo-proliferative syndromes, multiple myeloma, acute and chronic lymphatic leukaemia, solid tumour, sepsis or trauma, the concentration of circulating proteasome has been found to be elevated, to correlate with the disease state, and may have prognostic significance. Proteasome levels have been measured by enzyme-linked immunosorbent assay (ELISA) techniques in cell lysates, serum or plasma samples. This approach has been used to show that proteasome concentrations in peripheral blood are elevated in patients with certain types of malignant diseases, including multiple myeloma, suggesting that circulating proteasome levels may be correlated with tumour burden. The link between elevated circulating proteasome levels and disease activity has also been demonstrated in patients with systemic autoimmune diseases.{{1384263-83-5} MedChemExpress|{1384263-83-5} Technical Information|{1384263-83-5} In stock|{1384263-83-5} custom synthesis} The ELISA plate is coated with the capture antibody and the proteasome sample is added and allowed to complex with the bound antibody. The detection antibody is then added, followed by the secondary antibody. Subsequent reaction between the activated TMB substrate/chromogen complex and horseradish peroxidase (HRP) conjugated secondary antibody produces a blue colored solution. After reaching the desired color intensity, the reaction is terminated by addition of the stop solution, which changes the solution color from blue to yellow. The plate is then analyzed at 450nm using a UV-Vis spectrophotometric plate reader.{{865433-00-7} web|{865433-00-7} Purity & Documentation|{865433-00-7} In Vivo|{865433-00-7} custom synthesis} The ELISA plate is coated with the capture antibody and the proteasome sample is added and allowed to complex with the bound antibody.PMID:20301626 The detection antibody is then added, followed by the secondary antibody. Subsequent reaction between the activated TMB substrate/chromogen complex and horseradish peroxidase (HRP) conjugated secondary antibody produces a blue colored solution. After reaching the desired color intensity, the reaction is terminated by addition of the stop solution, which changes the solution color from blue to yellow. The plate is then analyzed at 450nm using a UV-Vis spectrophotometric plate reader.

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Solubility:

Formula:

Additional Information :
| Application ELISA | Application Notes For quantification of 20S proteasome levels in biological samples noting that the kit is not suitable for mouse or rat samples. | Assay Time | Contents Plate, Capture Antibody, Detection Antibody, Conjugated Antibody, Proteasome Stock Solution, Binding Buffer, Wash Buffer, Blocking Buffer, ELISA Buffer, Lysis Buffer, TMB Substrate Solution, Stop Solution | Quantity 96 wells (24 tests in triplicate) | Species Reactivity Human | Wavelength 450 nm