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DC260126 is a potent antagonist of GPR40 (FFAR1). DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid, oleic acid, palmitoleic acid and lauric acid (IC50: 6.28, 5.96, 7.07, 4.58 μM, respectively). DC260126 could protect MIN6 β cells from palmitate-induced ER stress and apoptosis.|Product information|CAS Number: 346692-04-4|Molecular Weight: 307.38|Formula: C16H18FNO2S|Chemical Name: N-(4-butylphenyl)-4-fluorobenzene-1-sulfonamide|Smiles: CCCCC1C=CC(=CC=1)NS(=O)(=O)C1C=CC(F)=CC=1|InChiKey: CNGHPXKWPGIDSK-UHFFFAOYSA-N|InChi: InChI=1S/C16H18FNO2S/c1-2-3-4-13-5-9-15(10-6-13)18-21(19,20)16-11-7-14(17)8-12-16/h5-12,18H,2-4H2,1H3|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : ≥ 100 mg/mL (325.33 mM)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Teropavimab} MedChemExpress|{Teropavimab} HIV|{Teropavimab} Activator|{Teropavimab} Technical Information|{Teropavimab} Description|{Teropavimab} custom synthesis} |Shelf Life: ≥360 days if stored properly.PMID:33207974 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|DC260126 reduces GTP-loading and ERK1/2 phosphorylation stimulated by linoleic acid in GPR40-CHO cells, suppresses palmitic acid potentiated glucose-stimulated insulin secretion, and negatively regulates GPR40 mRNA expression induced by oleic acid in Min6 cells.|References:|Hu H, et al. A novel class of antagonists for the FFAs receptor GPR40. Biochem Biophys Res Commun. 2009;390(3):557-563.Wu J, et al. Inhibition of GPR40 protects MIN6 β cells from palmitate-induced ER stress and apoptosis [published correction appears in J Cell Biochem. 2013 May;114(5):1216]. J Cell Biochem. 2012;113(4):1152-1158.Products are for research use only. Not for human use.|

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GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT).|Product information|CAS Number: 109053-09-0|Molecular Weight: 711.81|Formula: C31H53N9O10|Chemical Name: (2S)-2-{2-[(2S)-2-[(2S,3S)-2-{2-[(2S)-2-{[(2S)-1-(2-aminoacetyl)pyrrolidin-2-yl]formamido}-4-methylpentanamido]acetamido}-3-methylpentanamido]propanamido]acetamido}-4-carbamoylbutanoic acid|Smiles: CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)CN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O|InChiKey: BLNMYSBCIVAVFK-PFZXUFBWSA-N|InChi: InChI=1S/C31H53N9O10/c1-6-17(4)26(30(48)36-18(5)27(45)34-14-23(42)37-19(31(49)50)9-10-22(33)41)39-24(43)15-35-28(46)20(12-16(2)3)38-29(47)21-8-7-11-40(21)25(44)13-32/h16-21,26H,6-15,32H2,1-5H3,(H2,33,41)(H,34,45)(H,35,46)(H,36,48)(H,37,42)(H,38,47)(H,39,43)(H,49,50)/t17-,18-,19-,20-,21-,26-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Bardoxolone} medchemexpress|{Bardoxolone} Necroptosis|{Bardoxolone} Protocol|{Bardoxolone} In Vitro|{Bardoxolone} manufacturer|{Bardoxolone} Cancer} |Shelf Life: ≥12 months if stored properly.{{Fmoc-Ser(tBu)-OH} medchemexpress|{Fmoc-Ser(tBu)-OH} {Amino Acid Derivatives}|{Fmoc-Ser(tBu)-OH} Activator|{Fmoc-Ser(tBu)-OH} Protocol|{Fmoc-Ser(tBu)-OH} Formula|{Fmoc-Ser(tBu)-OH} supplier} |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.PMID:32490699 |Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|GPLGIAGQ is used to trigger PEG deshielding of liposomal carriers, resulting in enhanced cellular internalization.|Products are for research use only. Not for human use.|

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Product information|CAS Number: 352323-25-2|Molecular Weight: 379.52|Formula: C16H17KN2O4S|Chemical Name: potassium (2S,5R,6R)-3,3-dimethyl-7-oxo-6-{2-[(2,3,4,5,6-²H₅)phenyl](2,2-²H₂)acetamido}-4-thia-1-azabicyclo[3.{{Hirudin} MedChemExpress|{Hirudin} Apoptosis|{Hirudin} Technical Information|{Hirudin} Data Sheet|{Hirudin} manufacturer|{Hirudin} Autophagy} 2.{{Rucaparib} MedChemExpress|{Rucaparib} Epigenetics|{Rucaparib} Technical Information|{Rucaparib} References|{Rucaparib} custom synthesis|{Rucaparib} Epigenetics} 0]heptane-2-carboxylate|Smiles: [K+].PMID:32310431 [2H]C([2H])(C(=O)N[C@H]1[C@H]2SC(C)(C)[C@H](C([O-])=O)N2C1=O)C1C([2H])=C([2H])C([2H])=C([2H])C=1[2H]|InChiKey: IYNDLOXRXUOGIU-RSWIJXEESA-M|InChi: InChI=1S/C16H18N2O4S.K/c1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9;/h3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22);/q;+1/p-1/t11-,12+,14-;/m1./s1/i3D,4D,5D,6D,7D,8D2;|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|Products are for research use only. Not for human use.|

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Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm).|Product information|CAS Number: 75168-11-5|Molecular Weight: 472.50|Formula: C26H38BrN3|Chemical Name: 3,6-bis(dimethylamino)-10-nonylacridin-10-ium bromide|Smiles: [Br-].CCCCCCCCC[N+]1C2=CC(=CC=C2C=C2C=CC(=CC=12)N(C)C)N(C)C|InChiKey: DRBHTUDHPPBMCD-UHFFFAOYSA-M|InChi: InChI=1S/C26H38N3.BrH/c1-6-7-8-9-10-11-12-17-29-25-19-23(27(2)3)15-13-21(25)18-22-14-16-24(28(4)5)20-26(22)29;/h13-16,18-20H,6-12,17H2,1-5H3;1H/q+1;/p-1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Solubility: DMSO : 25 mg/mL (52.{{Dolutegravir} medchemexpress|{Dolutegravir} Metabolic Enzyme/Protease|{Dolutegravir} Purity & Documentation|{Dolutegravir} Formula|{Dolutegravir} custom synthesis|{Dolutegravir} Cancer} 91 mM; Need ultrasonic).|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vivo:|Acridine Orange 10-Nonyl Bromide is a fluorescent probe for cardiolipin (λex: 489 nm, λem: 525 nm) which can be used to quantify the cardiolipin in isolated mitochondria.{{Phosphatidylethano lamine} medchemexpress|{Phosphatidylethano lamine} Metabolic Enzyme/Protease|{Phosphatidylethano lamine} Technical Information|{Phosphatidylethano lamine} Data Sheet|{Phosphatidylethano lamine} supplier|{Phosphatidylethano lamine} Cancer} when Acridine Orange 10-Nonyl Bromide interacts with cardiolipin, the dye excitation and emission wave lengths shift from 496 and 525 nm to 450 and 640 nm, respectively.PMID:33125288 Increasing amounts of cardiolipin (0 to 30 μM) and other acidic phospholipids in thin-walled vesicles added to Acridine Orange 10-Nonyl Bromide (45 μM) changes the red fluorescence emission measured at 640 nm according to the liposome composition.|Products are for research use only. Not for human use.|